The second round of treatment:

Name: Zinhle Manzini
Sex: Female
Nationality: South African
Age: 41Y
Diagnosis: Polymyositis
Date of Admission: November 17th, 2016
Treatment hospital/period: Wu Medical Center/14 days

Before treatment:
Zinhle Manzini felt weakness in her legs 10 years ago. It was hard for her to go up and down stairs, squat, stand up from sitting in a chair and other movements. Her CK level was high and she was diagnosed with polymyositis. The doctor prescribed immunodepressant but it made no improvement. Her disease progressed slowly and she went to our hospital 6 months ago. After the treatment her muscle power and balance function were better. At present, her left side muscle power is weaker than the right side and she is able to walk for  1000 meters . She wants a better life so she came to our hospital.
Her spirit, appetite, sleep, bladder and bowel actions are normal.

Admission PE:
Bp: 125/78mmHg;Hr: 79/min; body temperature: 36.7 degrees. Her nutrition was good. Her skin mucosa was normal and she had no yellow stain or bleeding spots. Her gums had mild swelling but no ulcers. Her thorax was symmetrical. The respiration of both lungs was clear, with no dry or moist rales. There was no pleural friction sound. Her heart rhythm was regular and strong, without obvious murmur in the valves. Her abdomen was flat and soft with no mass inside. Bowel sound was normal. Her liver and spleen were normal under palpate touch. The legs had no edema.

Nervous System Examination:
Zinhle Manzini was alert and her speech was clear. She had a normal orientation, memory and calculation. The diameter of both pupils was 2.5mms, and both pupils were equal in size and round. Her vision and vision field were normal. There was no nystagmus and the pupils reacted normally to light stimulus. She had symmetrical forehead wrinkles and she had a normal chewing ability. Her nasolabial groove was equal in depth. The corners of her mouth were symmetrical when she displayed her teeth. She could raise her soft palate normally. She had no air leaking when she blew out her cheeks. Her tongue was in the middle of the oral cavity and her hearing was good. She turned her neck and shrugged her shoulders normally. The muscle strength of her arms was at level 5/5. The muscle strength of her legs was at level 4/5. The muscle tone of all four limbs was normal. The bilateral bi-ceps reflex was normal but radioperiosteal reflex or achilles tendon reflex cannot be elicited. The abdominal reflex can be elicited. Bilateral pathological sign was negative. The deep and shallow sensibility was normal. Bilateral finger-to-finger test, fast rotation test, and finger-to-nose test were normal. Bilateral heel-knee-shin test could be done in a slow way. The Romberg’s sign was positive. She could stand on the right foot for 20 seconds and she could stand on her left foot for just 5 seconds. She did not walk a straight line very well. The meningeal irritation sign was negative.

Treatment:
After admission Zinhle was diagnosed with Polymyositis. She received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair her damaged muscle cells, replace dead muscle cells with new injected stem cells, nourish muscle cells, regulate her immune system and improve blood circulation. She also had rehabilitation training.     

Post-treatment:
After 14 days of treatment, Zinhle Manzini’s balance was better than before. The walking gait has improved. She was able to stand on one foot for a longer time, right foot 30s, left foot 10s.

The first round of treatment:
Admission Date: 2016-4-16
Treatment hospital/period: Wu Medical Center/14 days

Before treatment:
Without a known cause, Zinhle developed weakness in the lower limbs ten years ago, and she had difficulty climbing the stairs, crouching down or getting up from chairs. Her CK (creatine kinase) level was obviously higher. She was diagnosed with “Polymyositis” at her local hospital and was given Imuran 100 mg/day, prednisone 20 mg/ day, vitamin B6 / day and INH2 2 tablets / day. The progression of the symptoms slowly became aggravated. The weakness in the lower limbs didn’t improve, and her walking gait became unstable and she was unable to walk long distances and she could not climb the stairs independently. Since the onset of her disease, she has been in good spirits, her appetite is normal and she gets normal amounts of sleep. Her urination routine and bowel movements are normal and her weight has increased by 20 kg.

Admission PE:
Bp: 125/80mmHg; Hr: 84/min; body temperature: 36.5 degrees and her breathing rate is 18 times/ minute. She has medium nutrition. There are no yellow stains or bleeding spots on her skin or mucosa. There is no congestion in the thorax, the tonsils are not swollen and the breathing sounds of both lungs were clear, with no dry or moist rales. The heart rhythm was regular, without obvious murmur in the valves. Her abdomen is full and it does not have pressing pain or rebound tenderness. Her liver and spleen are not swollen and it has hyperresonant after tapping it. There are deformities in her limbs and spinal cord. There is no swelling in the lower limbs.CK result is: CK 549U/L(normal CK＜167).

Nervous System Examination:
Zinhle Manzini was alert. Her speech was clear. She had normal orientation, memory and calculation ability. The pupils reacted normally to light stimulus, and her vision and vision field were normal. The forehead wrinkle pattern was symmetrical. She had normal chewing ability. Her nasolabial groove was equal in depth. The corners of the mouth were symmetrical when she displayed her teeth. The soft palate could be raised powerfully. There was no air leaking when she expanded her cheeks. The tongue was centered in the oral cavity. The neck could turn flexibly and the shoulders shrugged powerfully. The muscle strength of the upper limbs was at level 5/5. The muscle strength of the lower limbs was at level 3/5.
The muscle tension in all four limbs was normal, and the bilateral biceps reflex was normal. The abdominal reflex was negative. The bilateral pathology was negative. The bilateral deep and shallow sensation was normal. The bilateral finger-to-finger test, rapid rotation test and finger-to-nose test were normal. The bilateral heel-knee-tibia test was performed in a slow but accurate way. She was not able to stand on one feet and it was hard for her to walk in a straight line. The meningeal irritation sign was negative. 

Treatment:
Zinhle was diagnosed with polymyositis. She was given three mesenchymal stem cells transplants and three neural stem cells transplants in order to initiate the repairing and regeneration of muscle cells and to activate the stem cells. She was given nutrition for the muscles and nerves, had the circulation improved, regulated the immune system and supported the treatment with rehabilitation therapy.

Post-treatment:
Within 14 days, the power of the lower limbs had improved. The muscle power was level four, her balance had improved, and her standing position and walking ability improved. Her gait improved when she walked, and her distance of her strides increased greatly. Her stamina also improved. She was able to walk up and down the stairs by herself. The result of her CK is 252U/L, decreased greatly.

E-mails:

Date:2016-8-15

Hallow

Hope you are well. Im improving even though I still get weak sometimes. I will be buying the medication soon but I still have the supply I bought while that side. Please find out for me if I can have another procedure after 6 months.

Keep well
Zinhle Manzini

Date:2017-3-4

Good day

Hope you are well. I have been doing well. No new weakness and I have been doing my physical training with my Biokibetisist. I wrote to Brittani asking if I could have my last blood results that I did so that I can share with my Doctor but I have not had any response from her. Please assist.

Regards
Zinhle Manzini