Clinical study of neural stem cell transplantation for the treatment of spinal cord injury
By:Like Wu , Xiaojuan Wang , Bo Cheng, Saichun Chu, Shuangshuang Liu , Xinrui Xi , Fang Peng , Xiang Wang , Xueyan Feng Abstract: Objective: To evaluate clinical therapeutic effect of the neural stem cell (NSC)transplantation for the treatment of spinal cord injury(SCI). Key words: Neural stem cell transplantation, spinal cord injury
For the patients with SCI, there was no effective treatment with traditional medicine. NSC transplantation is a new type of therapy. This paper described the clinical effect of NSC transplantation on 45 SCI patients. The result are summarized as follows: Materials and Methods Treatment: Time: 3-4 weeks, treatment method: 4 times embed neural stem cells in the spinal subarachnoid space 5 million each, 20 million in all, at the same time assisted with neural activation and rehabilitation. Our center referred American Spinal Injury Association (ASIA)’s SCI functional assessment to evaluated our patients’ neurological. We evaluated patients’ AIS(ASIA Impairment Scale,AIS) again after treatment. A-SIA assessment was including the evaluation of touching, pinpricking, sporting and perspiration.
Discussion NSC is a efficacious nervous system tissue engineering seed cell. When treating SCI, NSC can generate neurons and glial cells after differentiation, these cells modulate the microenvironment of the spinal cord and inducing axonal regeneration by means of secreting a variety of neurotrophic molecules. Furthermore, NSC produces a variety of extracellular matrix to fill the cavity caused by injury and support axonal regeneration. It can also promotes residual myelin’s nerve fibers changing into new myelin to complete the nerve fibers. After treatment the Conclusion is: Patients’ AIS changing: 8 ALS patients in level A turned to level C, 25 patients turned to level B. 11 ALS patients in level B turned to level C, one patient's reminded unchanged. The score is significantly higher than before(P<0.05). So NSC transplantation has significantly changed SCI patients’ conditions including sensory, motor, perspiration.
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