Name: Danilo Marinozzi
Sex: Male
Country: Italy
Age: 27 years
Diagnoses: Spinal cord injury
Admission Date: 2013-04-28
Days Admitted to the Hospital: 28

Before treatment:
The patient suffered from car accident on November 15, 2009. He was in a coma and had difficulty breathing. He was diagnosed with transverse spinal cord injury and lung contusion. He received operation and implanted titanium plate. He also received treatment for lung contusion. 20 days later, the patient came round. He couldn't recall the whole car accident completely and the breath state was improved. The patient had severe bedsore and was kept in bed for 2 years. Then the bedsore healed gradually. He started rehabilitation exercise. He always injected enoxaparin 4000iu qn. At present, the patient's both lower limbs was completely paralyzed

. The lower limbs had no sensation. He couldn't take care of himself. After the car accident, the patient suffered from obvious asitia and had no hunger sensation. He used many medications, but no good effect.

Admission PE:
Bp: 115/65mmHg; Hr: 58/min. He had malnutrition and was thin. The skin and mucosa were normal, with no petechia or yellow stains. There was a surgery scars in the center of the neck and back. There was a scar from an operation which has healed well, with no ulceration. There was a scar from a bedsore on the sacrococcygeal region and the scar had healed. The surface of the skin was not smooth, with no ulceration or exudation. The sweat on both sides of the face was unequal. The facial pores on the right side were smaller than the left side. The skin on the right side of the face was drier than the left side. There was no congestion in the pharyngeal. There was no enlargement of the tonsils. The thorax was symmetrical. The respiratory sounds in both lungs were clear, with no dry or moist rales. The cardiac rate was normal and the heart sound was strong. The heart rate was 58/min. There was no obvious murmur in auscultatory valve areas. The abdomen was soft and sunken, with no obvious masses. We were unable to touch the liver or spleen under the rib. The borborygmus was present normally through auscultation. The temperature and color of both heels were normal. The dorsal artery of the acrotarsium was beating strongly.

Nervous System Examination:
Danilo Marinozzi was alert. His speech was fluent. His memory, calculation and orientation abilities were normal. The pupils were equal in size, the diameter was 3.0 mm and the pupils reacted normally to light stimulus. Both pupils move freely. The forehead wrinkle pattern was symmetrical. The tongue was centered in the oral cavity and the teeth were shown without deflection. Danilo's neck could move flexibly. He could shrug shoulders normally. The muscle tone of both upper limbs was normal. The muscle tone of both lower limbs was low. The muscle strength of both upper limbs was level 5, the muscle strength of both lower limbs was level 0. The tendon reflex of both upper limbs was normal. Bilateral abdominal reflexes were disappeared. The tendon reflex of both lower limbs was disappeared. The warm sensation, pain sensation and touch sensation above thoracic vertebra 2 segments existed normally. The touch sensation and pain sensation below thoracic vertebra 2 segments was slowed down. The pain sensation below left thoracic vertebra 6 was not present. The pain sensation below right thoracic vertebra 8 has disappeared. The vibration sense below both thoracic vertebra 3 was slowed down. The vibration sense below both thoracic vertebra 8 has disappeared. The cremasteric frelex was disappeared. Bilateral Hoffmann sign and Rossilimo sign were negative. Bilateral palm jaw reflex was negative. Bilateral Babinski sign was negative. The coordinate movement examination of both upper limbs was normal. The patient was unable to finish coordinate movement examination of both lower limbs.

Treatment:
We initially gave Danilo Marinozzi a complete examination and he was diagnosed with a spinal cord injury. Then we proceeded with the nerve nutrition, and improved the blood circulation to increase the blood supply to the damaged neurons. He also received treatment for nerve regeneration and activate internal stem cells. This was combined with daily physical rehabilitation training.

Post-treatment:
The patient has hunger sensation and the diet is better. The food-intake is almost normal. The moisture degree of both face and bilateral neck are almost the same. The pain sensational flat and warm sensational flat are down to thoracic vertebra 3. He had abdominal reflexes of superior belly and middle belly. Both lower limbs had 1 level muscle strength and weak patellar tendon reflex. The cremasteric frelex is restored. He can transfer his trunk.

The second round treatment:

Name:Danilo Marinozzi

Sex:Male

Age:28 years old

Country: Italy

Diagnosis: Spinal cord injury

Admission Date: 2014-01-03

Days Admitted to the Hospital:28

Before treatment:

The patient suffered from car accident on November 15, 2009. He felt into coma and had difficulty breathing. He was sent to a local hospital and was diagnosed with transverse spinal cord injury and lung contusion. He received operation and titanium plate implant. He also received treatment for lung contusion. 20 days later, the patient came round. He couldn't recall the whole car accident completely but the breathing state was improved. The patient had severe bedsore because he was kept in bed for 2 years. The patient's lower limbs still had no autonomic activities, but he still almost could transfer his body. With the assistance of his arms, the patient could sit-up, but the sitting position was unstable, the balance ability was poor. He had poor diet. There was obvious muscle atrophy in his lower limbs. He could take care of himself partly. The patient received treatment in our hospital in May 2013. After treatment, the patient had better appetite. The muscle volume of both lower limbs improved. The balance in sitting position was improved obviously. For further progress, the patient came to our hospital again.

From the onset of disease, the diet was not good. The quality of food intake reduced obviously in 4 months. He had no sense of hunger. He had regular sleep. He needed abdominal massage for defecation. He needed intermittent catheterization and this was done 6 times each day.

Admission PE:
Bp: 130/70mmHg; Hr: 56/min. The nutrition was normal. There was a surgical scar at the centre of the neck and back, the scar was about 20cm. The scar was from an operation which has healed well. There was a scar from a bedsore on the sacrococcygeal region and the scar had healed. The surface of the skin was not smooth, with no ulceration or exudation. There was no congestion in the pharyngeal. There was no enlargement of the tonsils. The thorax was symmetrical. The respiratory sounds in both lungs were clear, with no dry or moist rales. The cardiac rate was normal and the heart sound was strong. The heart rate was 58/min. There was no obvious murmur in auscultatory valve areas. The abdomen was soft and sunken, with no obvious masses. We were unable to touch the liver or spleen under the rib. The borborygmus was present normally through auscultation. The temperature and color of both heels were normal. The dorsal artery of the acrotarsium was beating strongly.

Nervous System Examination:
Danilo Marinozzi was alert. His speech was fluent. His memory, calculation and orientation abilities were normal. The pupils were equal in size, the diameter was 3.0 mm and the pupils reacted normally to light stimulus. Both pupils move freely. The forehead wrinkle pattern was symmetrical. The tongue was centred in the oral cavity and the teeth were shown without deflection. Danilo's neck could move flexibly. He could shrug shoulders normally. The muscle tone of both upper limbs was normal. The muscle tone of both lower limbs was low. The muscle strength of both upper limbs was at level 5, the muscle strength of both lower limbs at was level 0. The tendon reflex of both upper limbs was normal. Bilateral abdominal reflexes were presented. The tendon reflex of both lower limbs was not elicited normally. The pain sensation below thoracic vertebra 2 segments was slowed down. The pain sensation below thoracic vertebra 4 was presented. Bilateral Hoffmann sign and Rossilimo sign were negative. Bilateral palm jaw reflex was negative. Bilateral Babinski sign was negative. Bilateral ankle clonus was negative. The coordinate movement examination of both upper limbs was normal. The patient was unable to finish coordinate movement examination of both lower limbs.

Treatment:
We initially gave Danilo Marinozzi a complete examination and he was diagnosed with spinal cord injury. Then we proceeded with the nerve nutrition, and improved the blood circulation to increase the blood supply to the damaged neurons. He also received nerve cell activation treatment and nerve regeneration. This was combined with daily physical rehabilitation training.

Post-treatment:
The patient has better diet. He has normal sense of hunger. The food-intake is almost normal. Part physiological reflex is presented. Bilateral abdominal reflexes were normal. Bilateral cremasteric reflex is more sensitive than before. The muscle strength of waist and back has increased. The balance in sitting position is better. There are muscle contractions in both lower limbs' near end; the muscle strength of lower limbs was at 1-2 level. The patient can stand with bent hips and knees in non-smooth flat, with lower limbs upright. He can do a few abduction and adduction movement.

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Date: 2014-09-16

Dear, next week I will send you the results of the test of the heart. however since I started treatments with stem cells, I feel much better. my intention is to come back for the third time in Beijing to do the treatment. towards the end of October. What do you think Dr. Wu? OK?
 
Best regardes.